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Leukoagglutination and pooling of granulocytes in the recipient's lungs may occur, with release of the contents of leukocyte granules, and resulting injury to cellular membranes, endothelial surfaces, and potentially to lung parenchyma. In most cases leukoagglutination results in mild dyspnea and pulmonary infiltrates within about 6 hours of transfusion, and spontaneously resolves. Leukocyte filters may prevent TRALI for those patients whose lung injury is due to leukoagglutination of the donor white blood cells, but because most TRALI is due to donor antibodies to leukocytes, filters are not helpful in TRALI prevention. Transfused plasma (from any component source) may also contain antibodies that cross- react with platelets in the recipient, producing usually mild forms of posttransfusion purpura or platelet aggregation after transfusion. 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In 9. 0 percent of reported cases, antibodies were present in the donor plasma; in 1. The second hypothesis suggests that neutrophils accumulate and are primed in the patient's pulmonary microvasculature as a result of preexisting systemic inflammation. Activation of these neutrophils by lipids or other mediators, such as CD4. L, which accumulate in cellular blood components during storage, contributes to endothelial damage in susceptible patients, leading to vascular leaks and pulmonary edema. Because 2. 0 percent of blood components contain HLA antibodies yet TRALI is relatively uncommon, it is conceivable that additional factors play a role in the development of TRALI. The typical presentation of TRALI is the sudden development of dyspnea, severe hypoxemia (O2 saturation < 9. Although hypotension is considered one of the important signs in diagnosing TRALI, hypertension can occur in some cases. 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